When it comes to mild to severe traumatic brain injury there seems to be little guidance from emergency room doctors or primary care about what is the best way to help the brain and body recovery after concussion. It's often the "watch and wait" approach to make sure the condition doesn't get worse.
For more severe accidents, emergency rooms will often order a CT scan to make sure there is no bleeding in the brain, but other than this, there is little support.
This blog post is a guide to the top supplements to use after a concussion to help with a smooth recovery.
We have compiled a list of the top studied supplements for brain recovery post concussion, but these also apply beyond just concussion recovery. They are for anyone who is experiencing brain fog, memory issues, fatigue, post-viral syndromes, or any other brain or nervous system condition -- including prevention of neuro-degenerative diseases.
Without further adieu, lets get into the top supplements and why they are useful.
For easy access, here is the link to my Fullscript Practitioner Page where you will have access to these supplements and more in one, easy to order place:
Medical Disclaimer:
The information provided in this blog post is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this blog. If you have any concerns about your health, consult a healthcare professional before taking any action based on the content provided here.
Omega-3 fatty acids:
Particularly DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), have shown potential in supporting brain recovery, reducing inflammation, and promoting neuroprotection. However, the optimal dosage is not universally standardized, and recommendations may vary based on the severity of the injury, age, and overall health status.
Suggested Omega-3 Dosage for Post-Concussion Recovery:
Mild to Moderate Concussions:
DHA: 2,000 – 3,000 mg per day
EPA: 1,000 – 2,000 mg per day
DHA is prioritized for brain recovery, as it is a major structural component of brain tissue.
Severe Traumatic Brain Injury (TBI):
DHA: Up to 3,000 – 5,000 mg per day
EPA: 2,000 – 3,000 mg per day
Higher doses may be beneficial under medical supervision for neuroinflammation control.
Maintenance Post-Recovery:
DHA: 500 – 1,000 mg per day
EPA: 500 – 1,000 mg per day
This helps to support long-term brain health and prevent cognitive decline.
Timing and Administration Recommendations:
Loading Phase: Some protocols suggest starting with a higher dose (e.g., 4,000–6,000 mg combined EPA/DHA) in the first week post-injury to maximize neuroprotection.
Maintenance Phase: Gradually taper to a lower dose for sustained support.
With Meals: Take omega-3 supplements with meals containing healthy fats for better absorption.
Key Considerations:
Form: Choose high-quality triglyceride or phospholipid forms (e.g., fish oil, krill oil, or algal oil for vegetarians). Providing both fish oil based and other that is for our vegans.
Curcumin:
The active compound in turmeric, has powerful anti-inflammatory, antioxidant, and neuroprotective properties, making it a promising supplement for post-concussion recovery. It may help reduce neuroinflammation, oxidative stress, and support cognitive function following a traumatic brain injury (TBI).
Suggested Curcumin Dosage for Post-Concussion Recovery:
Standard Dosage (Mild to Moderate Concussion):
500 – 1,500 mg per day, divided into 2–3 doses.
Use a high-absorption form such as curcumin with piperine (black pepper extract) or liposomal curcumin for better bioavailability.
Severe Concussions or Traumatic Brain Injury (TBI):
1,500 – 3,000 mg per day, split into multiple doses.
Higher doses should be taken under medical supervision to monitor effects and avoid gastrointestinal discomfort.
Maintenance Post-Recovery:
500 – 1,000 mg per day to support long-term brain health and via inflammation reduction
Precautions:
May interact with blood thinners or medications that affect liver enzymes.
High doses can cause mild digestive upset; start with a lower dose and increase gradually.
Always consult with a healthcare provider before starting supplementation, especially for individuals with underlying medical conditions.
Magnesium:
The best type of magnesium post-concussion is Magnesium L-Threonate, as it is the most effective form for supporting brain health and cognitive function. It has been shown to cross the blood-brain barrier efficiently, increasing magnesium levels in the brain, which is crucial for neuroprotection and recovery after a concussion.
Magnesium L-Threonate (Best for Brain Health)
Why:
Specifically formulated to penetrate the brain and support cognitive function.
Enhances synaptic plasticity, memory, and learning.
Helps in reducing brain fog, headaches, and neuroinflammation post-concussion.
Suggested Dose:
1,500 – 2,000 mg per day (providing approximately 144 mg of elemental magnesium).
Split into 2–3 doses daily.
Vitamin D
Regulation of Neurotrophic Factors (Brain Growth & Repair)
Vitamin D enhances the production of nerve growth factors such as brain-derived neurotrophic factor (BDNF), which supports neuronal survival, growth, and plasticity.
BDNF plays a vital role in memory formation and learning, aiding in the recovery of cognitive function after brain injuries.
Vitamin C
Reduces [neuro]inflammation
Vitamin C suppresses the release of pro-inflammatory cytokines (such as IL-6 and TNF-α), which contribute to neuroinflammation post-concussion or in neurodegenerative diseases.
This anti-inflammatory action helps prevent neuronal damage and supports faster recovery from brain injuries.
Note:
In our Fullscript recommendation list, the supplement by Integrative Therapeutics called Magtein L-Threonate Plus is a convenient combination of Magnesium threonate, vitamin D and vitamin C.
N-Acetylcysteine (NAC)
Is a powerful neuroprotective supplement known for its antioxidant, anti-inflammatory, and neuro-regenerative properties. It serves as a precursor to glutathione, the body's most potent antioxidant, and plays a crucial role in maintaining brain health, particularly after injuries like concussions and in neurodegenerative conditions.
Post-Concussion Recovery:
1,200 – 2,400 mg per day, divided into 2–3 doses.
Start within 24–48 hours post-injury if possible for maximum benefit.
General Brain Health and Neurodegeneration:
600 – 1,800 mg per day, depending on the condition and individual needs.
NAC may thin the blood, so caution is advised if taking anticoagulant medications
Phosphatidylserine (PS)
Is a phospholipid that is crucial for brain health and cognitive function. It is a major component of cell membranes, particularly in neurons, and plays a vital role in maintaining cell membrane integrity, neurotransmitter function, and cognitive processes.
It is widely recognized for its neuroprotective properties, making it beneficial for concussion recovery, cognitive decline, and mental performance.
Phosphatidylserine for Post-Concussion Recovery
Helps with memory recall, attention, focus, and brain fog following a concussion.
Supports overall brain cell repair and neuroplasticity.
Reduces cortisol levels that can increase due to post-concussion stress.
Recommended Dosage for Neuroprotection and Cognitive Support
General Brain Health and Memory Support:
100–200 mg per day
Post-Concussion Recovery or Cognitive Decline:
300–400 mg per day (divided into 2 doses)
Stress Reduction and Sleep Support:
200–300 mg before bedtime
Lion's Mane Mushroom (Hericium erinaceus)
Is a powerful natural nootropic and neuroprotective mushroom supplement known for its ability to support brain health, cognitive function, and nerve regeneration. It contains bioactive compounds that stimulate nerve growth factor (NGF), reduce neuroinflammation, and protect against neurodegeneration, making it beneficial for conditions such as concussions, traumatic brain injuries (TBI), neurodegenerative diseases, and cognitive decline.
Key Neuroprotective Benefits of Lion's Mane Mushroom:
Stimulates Nerve Growth Factor (NGF) Production
Lion's Mane contains compounds like hericenones and erinacines that boost the production of NGF, a protein crucial for the growth, survival, and repair of neurons.
NGF helps promote neurogenesis (the formation of new brain cells) and enhances synaptic plasticity, which is essential for learning and memory.
This makes it particularly useful for post-concussion recovery and neurodegenerative conditions.
Supports Brain Repair and Neuroregeneration
By promoting NGF, Lion’s Mane aids in the repair of damaged nerve cells and supports myelin regeneration, which is essential for efficient nerve signal transmission.
This is beneficial for individuals recovering from traumatic brain injuries or conditions such as multiple sclerosis (MS).
Enhances Cognitive Function (Memory, Focus, and Mental Clarity)
Lion’s Mane has been shown to improve short-term and long-term memory, focus, and mental clarity, making it an effective tool for students, professionals, and older adults looking to maintain cognitive health.
It supports faster cognitive processing and helps reduce “brain fog,” often experienced after a concussion.
Reduces Neuroinflammation
Chronic neuroinflammation is a key contributor to neurodegenerative diseases and post-concussion symptoms.
Lion’s Mane possesses strong anti-inflammatory and antioxidant properties that help protect neurons from oxidative damage and inflammation, which can slow down cognitive decline and accelerate brain healing.
Protects Against Neurodegenerative Diseases
Studies suggest Lion's Mane may help prevent or slow the progression of neurodegenerative conditions such as:
Alzheimer’s Disease: By reducing beta-amyloid plaque formation and supporting neuronal function.
Parkinson’s Disease: By protecting dopaminergic neurons and reducing oxidative stress.
Multiple Sclerosis: By promoting myelin sheath regeneration and reducing inflammation.
Alleviates Anxiety and Depression
Lion's Mane has mood-enhancing effects by regulating neurotransmitters such as serotonin and dopamine, which contribute to emotional stability and resilience.
It helps to alleviate symptoms of anxiety, depression, and stress, which are often prevalent in individuals recovering from concussions or dealing with chronic stress.
Enhances Gut-Brain Axis Health
Emerging research indicates a strong link between gut health and brain function. Lion's Mane has prebiotic properties that promote healthy gut bacteria, which in turn can support cognitive health and emotional well-being.
Protects Against Age-Related Cognitive Decline
Regular consumption of Lion’s Mane has been associated with a reduction in cognitive decline related to aging by maintaining neuronal plasticity and reducing oxidative stress in the brain.
Recommended Dosage for Neuroprotection:
General Cognitive Support:
500 – 1,000 mg per day of Lion’s Mane extract (with 20-30% beta-glucans).
Post-Concussion or Brain Injury Recovery:
1,000 – 3,000 mg per day, split into 2–3 doses.
Neurodegenerative Conditions:
2,000 – 3,000 mg per day, taken consistently for long-term benefits.
Take in the Morning: To support cognitive function and energy levels throughout the day.
L-Theanine
Benefits: L-Theanine is an amino acid found in tea leaves that promotes relaxation without drowsiness. It may help reduce anxiety, improve focus, and promote mental clarity, which can be disrupted after a concussion.
Sources: Green tea, L-theanine supplements.
Evidence: Some studies show that L-theanine can help improve mental clarity, reduce stress, and improve sleep quality, all of which are important for brain recovery.
Taurine
Benefits: Taurine is an amino acid that may support brain health by modulating calcium levels in the brain, reducing excitotoxicity (which can happen after a brain injury), and improving cellular function.
Sources: Taurine supplements, meat, fish.
Evidence: Some research suggests taurine may help protect against neurological damage and support brain cell recovery after trauma.
Alright folks, this is not an exhaustive list of all the supplements that are neuroprotective or anti-inflammatory, but it is a list of some of the most studied that are indeed shown to reduce inflammation and increase healing time and cognition.
Thank you so much for reading this post.
We want to leave you with two final resources.
Here is the link one more time to order some or all of these supplements from our online dispensary: https://us.fullscript.com/plans/vitalife-neuro-protective-and-inflammation-reduction
If you are unsure about ordering, or wish to have a consult with Dr. Christina, please contact our office at office@vitalife.center to ask about scheduling a telehealth appointment.
Yours warmly from Vital Life Center,
Dr. Christina and Team
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